Efecto del estado nutricional neonatal en la asociación entre polimorfismo rs9939609 del gen FTO y obesidad en niños chilenos de origen amerindio, Jorge Sapunar ...[et al.]
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Efecto del estado nutricional neonatal en la asociación entre polimorfismo rs9939609 del gen FTO y obesidad en niños chilenos de origen amerindio, Jorge Sapunar ...[et al.]
Language
spa
Abstract
Background: The presence of A allele in FTO gene is associated with a higher risk of obesity. Aim: To investigate the effect of neonatal nutritional status on the association between FTO gene rs9939609 variant and obesity in a cohort of Chilean children with Amerindian ancestry. Material and Methods: Using birth registries, the neonatal ponderal index of 238 obese and 136 normal weight children was calculated. Nutritional status of participants was determined using cutoff points proposed by the Center for Disease Control. FTO polymorphism was measured by real time polymerase chain reaction. Results: The presence of FTO A allele was associated with a higher risk of obesity (odds ratio (OR) 1.87 95% confidence intervals (CI) 1.14-3.06, p < 0.01). The effect of this allele was only significant among males. The risk of obesity associated with A allele presence was non-significantly higher among males with a neonatal ponderal index below percentile 10, as compared with their counterparts with a neonatal ponderal index above this value (OR 5.65 95% CI 0.87-60.4). A logistic regression analyzing the presence of A allele as a risk factor for obesity using neonatal nutritional status and gender as control variables, did not substantially change the results. Conclusions: There is a non-significant effect of neonatal undernutrition on the risk of obesity conferred by the presence of A allele of FTO gene. Key words: Amerindian, childhood obesity, FTO gene, genetic association studies, newborn, nutritional status
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Main title
Efecto del estado nutricional neonatal en la asociación entre polimorfismo rs9939609 del gen FTO y obesidad en niños chilenos de origen amerindio
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Jorge Sapunar ...[et al.]
Variant Title
Effects of neonatal undernutrition of the association of obesity with rs9939609 polymorphism of FTO gene among amerindian children
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